Related Experiment Video
Updated: May 6, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
Published on: July 5, 2017
Activation of eNOS by polyphenol-rich products and polyphenolic compounds
Jong Hun Kim, Cyril Auger, Valérie B Schini-Kerth1
1UMR CNRS 7213 - Laboratoire de Biophotonique et Pharmacologie, Université de Strasbourg - Faculté de Pharmacie, 74, route du Rhin, 67401 Illkirch, France. valerie.schini-kerth@unistra.fr.
Abstract:
Numerous epidemiological studies indicate that consumption of polyphenol-rich food and beverages is associated with a protective effect on the cardiovascular system. The beneficial effect has been attributable to several mechanisms including the improvement of the vascular function. Indeed, polyphenols have been shown to be potent stimulators of endothelial vasoprotective mechanisms including the formation of nitric oxide (NO) and the induction of endothelium-derived hyperpolarization (EDH). The aim of this review is to provide a non-exhaustive analysis of the literature regarding polyphenols-rich sources capable of activating endothelial NO synthase and the characterization of the underlying mechanism as well as the beneficial effects of polyphenols on the endothelial function in both experimental models of cardiovascular diseases and in Humans.
Related Concept Videos
Reactivity of Enols
Dehydration of Aldols to Enals: Base-Catalyzed Aldol Condensation
Oxidation of Phenols to Quinones
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
Enzymes and Activation Energy
Enzymes and Activation Energy
Radical Autoxidation

