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Updated: May 6, 2026
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Recent advances in LC-MS/MS analysis of Δ(9)-tetrahydrocannabinol and its metabolites in biological matrices
1pharmazentrum grankfurt/ZAFES, Institute of Clinical Pharmacology, Uniklinik der J. W. Goethe Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany. ferreirosbouzas@em.uni-frankfurt.de.
Abstract:
Cannabis is the most widely used illicit drug in the world. The pharmacological properties of Δ(9)-tetrahydrocannabinol also make it a promising molecule in the treatment of different pathologies. Understanding the PKs and PDs of this drug requires the determination of the concentration of Δ(9)-tetrahydrocannabinol and metabolites in biological matrices. For this purpose many analytical methodologies using mass spectrometric detection have been developed. In recent years, LC-MS/MS has become the gold standard in analysis of tetrahydrocannabinol and its metabolites due to the high selectivity and sensitivity, but above all, due to the ability to determine free and conjugate analytes in one run.
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