Related Experiment Video
Updated: Sep 21, 2026
Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge
Published on: April 9, 2012
The role of lymphocyte subpopulations in the transfer of rat EAE
The role of lymphocyte subsets in rat EAE was investigated using a passive transfer system in which spleen cells from sensitized donors were injected into naive recipients after incubation in culture for 72 h with myelin basic protein. The presence of anti-I-A antibody, but not anti-I-E antibody during incubation, prevented disease. In addition, removal of I-A+ cells by rosetting prior to injection eliminated the ability of the donor splenocytes from transferring disease while the simultaneous removal of both cytotoxic/suppressor and B cells had no effect on the disease outcome.
The role of lymphocyte subsets in rat EAE was investigated using a passive transfer system in which spleen cells from sensitized donors were injected into naive recipients after incubation in culture for 72 h with myelin basic protein. The presence of anti-I-A antibody, but not anti-I-E antibody during incubation, prevented disease. In addition, removal of I-A+ cells by rosetting prior to injection eliminated the ability of the donor splenocytes from transferring disease while the simultaneous removal of both cytotoxic/suppressor and B cells had no effect on the disease outcome.
More Related Videos
08:47Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
Published on: May 8, 2016
09:01Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
Published on: November 17, 2020