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[The expression of oncogene fms in human chorionic tissue]
Nihon Sanka Fujinka Gakkai Zasshi
|December 1, 1985
Summary
The oncogene fms is expressed in human chorionic tissue throughout pregnancy. Its role appears linked to cell differentiation rather than proliferation.
Area of Science:
- Molecular Biology
- Genetics
- Developmental Biology
Context:
- Oncogenes play roles in cancer and normal physiological processes.
- Understanding oncogene expression in placental tissue is crucial for developmental insights.
Purpose:
- To investigate the expression and localization of the oncogene fms in human chorionic tissue.
- To determine the potential role of fms in placental cell proliferation and differentiation.
Summary:
- The study utilized molecular hybridization (Northern blotting) and in situ hybridization to detect fms oncogene expression in first and third-trimester human placental tissue.
- Four kilobase RNA molecules homologous to fms-cDNA were identified in chorionic tissue, increasing towards term.
- fms-mRNA signals were localized to trophoblasts, independent of proliferative cell specificity.
Impact:
- This research demonstrates that the oncogene fms is expressed in human chorionic tissue during both early and late pregnancy.
- The findings suggest a potential role for fms in trophoblast cell differentiation, rather than solely in cell proliferation.