Histology of CorMatrix bioscaffold 5 years after pericardial closure

CorMatrix is a non-crosslinked, acellular bioscaffold used for pericardial closure and cardiac tissue repair. A redo sternotomy 5 years after bypass grafting and pericardial reconstruction afforded the opportunity to explant the bioscaffold and examine it histologically. Consistent with preclinical evidence, pathology results showed that the bioscaffold had remodeled into viable, fully cellularized, vascularized, non-fibrotic connective tissue similar to native pericardium.