Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sweet and Bright: Illuminating Glycoprotein-Mediated Endocytosis via Metabolic Labeling and NanoLuciferase.

ACS chemical biology·2026

Same author

TEAMSTER: End-to-end pipeline for generation, processing, and automated quantitative image analysis of 3D tumour spheroids for nanobiology.

Methods (San Diego, Calif.)·2026

Same author

Structural flexibility of the human vault particle revealed by high-resolution cryo-EM and molecular dynamics simulations.

Nature communications·2026

Same author

From biopolymers to Pickering emulsions: a green chemistry strategy to replace microplastics in next-generation cosmetics.

RSC advances·2026

Same author

Changes in ANA Positivity Following SARS-CoV-2 Outbreak in Lombardy Region, Italy.

Journal of medical virology·2026

Same author

Engineered Energy-Harvesting Hybrid Nanoscintillators for Enhanced Cancer Radiotherapy.

ACS applied materials & interfaces·2026

Search research articles

Related Experiment Video

Updated: May 6, 2026

Biofunctionalization of Magnetic Nanomaterials

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

Biotechnological approaches toward nanoparticle biofunctionalization.

Svetlana Avvakumova¹, Miriam Colombo², Paolo Tortora²

¹Dipartimento di Scienze Biomediche e Cliniche "L. Sacco", Università di Milano, via G. B. Grassi, 74, 20157 Milano, Italy.

Trends in Biotechnology

|November 5, 2013

Summary

This summary is machine-generated.

Researchers are advancing nanomedicine for cancer therapy by optimizing nanoconjugate design. Controlling nanoparticle size, shape, and ligand attachment is key for effective cancer cell targeting and drug delivery.

Keywords:

ligand orientation nanoparticles tailoring targeting tumor

More Related Videos

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

Procedure for Fabricating Biofunctional Nanofibers

Procedure for Fabricating Biofunctional Nanofibers

Published on: September 10, 2012

Related Experiment Videos

Last Updated: May 6, 2026

Biofunctionalization of Magnetic Nanomaterials

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

Procedure for Fabricating Biofunctional Nanofibers

Procedure for Fabricating Biofunctional Nanofibers

Published on: September 10, 2012

Area of Science:

Nanomedicine and nanotechnology
Bioconjugation chemistry
Cancer therapeutics

Background:

Nanomedicine offers promising therapeutic and diagnostic tools.
Targeted cancer therapy relies on nanoconjugates with specific bioactive ligands.
Optimizing nanoconjugate design is crucial for efficacy.

Purpose of the Study:

To review advances in immobilizing targeting proteins on nanoparticles.
To focus on methods controlling ligand orientation and density.
To highlight criteria for designing nanoparticles for enhanced receptor targeting.

Main Methods:

Overview of bioconjugation strategies for nanoparticle functionalization.
Analysis of nanoparticle design parameters (size, shape, ligand shell).
Discussion of methods to reduce nonspecific protein adsorption.

Main Results:

Bioconjugation approach significantly impacts targeting molecule orientation, accessibility, and bioactivity.
Controlled ligand orientation and density are critical for receptor-targeting efficiency.
Nanoparticle design parameters influence overall nanoconjugate performance.

Conclusions:

Careful selection of bioconjugation methods is essential for effective nanoconjugate design.
Optimized nanoparticle design enhances receptor-targeting efficiency in cancer therapy.
Further research in nanoconjugate development promises improved nanomedicine applications.