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A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
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On-column nitrosation of amines observed in liquid chromatography impurity separations employing ammonium hydroxide

David P Myers1, Evan M Hetrick, Zhongming Liang

  • 1Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.

Journal of Chromatography. A
|November 5, 2013
PubMed

Keywords:
AminesAmmonium hydroxideHLPCHigh pHImpuritiesNitrosamines

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