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Updated: May 6, 2026

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains
Published on: January 16, 2026
Scaling brain size, keeping timing: evolutionary preservation of brain rhythms
György Buzsáki1, Nikos Logothetis, Wolf Singer
1The Neuroscience Institute, Center for Neural Science, School of Medicine, New York University, New York, NY 10016, USA.
Abstract:
Despite the several-thousand-fold increase of brain volume during the course of mammalian evolution, the hierarchy of brain oscillations remains remarkably preserved, allowing for multiple-time-scale communication within and across neuronal networks at approximately the same speed, irrespective of brain size. Deployment of large-diameter axons of long-range neurons could be a key factor in the preserved time management in growing brains. We discuss the consequences of such preserved network constellation in mental disease, drug discovery, and interventional therapies.
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