Unmasking subtle differences in the infectivity of microevolved Mycobacterium tuberculosis variants coinfecting the
Yurena Navarro1, Laura Pérez-Lago, Fernanda Sislema
1Servicio Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain; CEI Campus Moncloa, UCM-UPM, Madrid, Spain; CIBER Enfermedades Respiratorias, CIBERES, Spain.
Abstract:
Clonal variants of Mycobacterium tuberculosis can emerge as a result of microevolution phenomena. The functional significance of these subtle genetic rearrangements is normally disregarded. We show that clonal variants from two patients had different infective behaviours in some in vitro cellular infection models but not in others. Microevolution may have a subtle impact on infectivity, but specific experimental conditions are needed to unmask it.
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