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Updated: May 6, 2026
06:51
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
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Acute oxalate nephropathy associated with Clostridium difficile colitis.
Abraham Cohen-Bucay1, Pranav Garimella2, Chukwudi Ezeokonkwo1
1Department of Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA.
Summary
Clostridium difficile-associated diarrhea can cause acute kidney injury due to acute oxalate nephropathy. This condition may arise from increased oxalate absorption in the colon.
Area of Science:
- Nephrology
- Gastroenterology
- Infectious Diseases
Background:
- Acute kidney injury (AKI) is a significant clinical concern.
- Clostridium difficile infection is a common cause of infectious diarrhea.
Observation:
- A 69-year-old male presented with AKI.
- The patient had community-acquired Clostridium difficile-associated diarrhea.
- Kidney biopsy confirmed acute oxalate nephropathy.
Findings:
- The case suggests a link between Clostridium difficile-associated diarrhea and acute oxalate nephropathy.
- Potential mechanisms involve increased intestinal permeability to oxalate.
Implications:
- Clostridium difficile-associated diarrhea should be considered in cases of unexplained AKI.
- Further research into the mechanisms of oxalate transport in C. difficile infection is warranted.
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