Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Asthma as an axon reflex.

P J Barnes

    Lancet (London, England)
    |February 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Asthma pathophysiology involves airway epithelial damage exposing nerve endings. This triggers axon reflexes, releasing neuropeptides that cause airway inflammation and smooth muscle contraction, suggesting new treatment strategies.

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Glucocorticoid resistance in asthma.

    American journal of respiratory and critical care medicine·1995
    Same author

    Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma.

    The Journal of experimental medicine·1995
    Same author

    Inhibition of macrophage inflammatory protein-1 alpha expression by IL-10. Differential sensitivities in human blood monocytes and alveolar macrophages.

    Journal of immunology (Baltimore, Md. : 1950)·1995
    Same author

    Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase.

    Molecular pharmacology·1995
    Same author

    Corticosteroid inhibition of macrophage inflammatory protein-1 alpha in human monocytes and alveolar macrophages.

    The American journal of physiology·1995
    Same author

    Cytokine expression in normal, atopic, and asthmatic subjects using the combination of sputum induction and the polymerase chain reaction.

    Thorax·1995
    Same journal

    Assisted dying and the silencing of medicine's next generation.

    Lancet (London, England)·2026
    Same journal

    Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

    Lancet (London, England)·2026
    Same journal

    Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

    Lancet (London, England)·2026
    Same journal

    [<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

    Lancet (London, England)·2026
    Same journal

    Research priorities for characterising Bundibugyo virus.

    Lancet (London, England)·2026
    Same journal

    Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

    Lancet (London, England)·2026
    See all related articles

    Area of Science:

    • Pulmonary Medicine
    • Neuroscience
    • Immunology

    Background:

    • Airway epithelium damage in asthma exposes C-fibre afferent nerve endings.
    • Eosinophil products may contribute to epithelial damage.

    Purpose of the Study:

    • To explore the role of axon reflexes in asthma pathophysiology.
    • To investigate the potential of targeting axon reflexes for asthma treatment.

    Main Methods:

    • Review of existing literature on asthma, C-fibres, and neuropeptides.
    • Conceptual analysis of the axon reflex mechanism in airway inflammation.

    Main Results:

    • Stimulation of exposed C-fibres by mediators like bradykinin initiates axon reflexes.
    • Antidromic conduction releases neuropeptides (Substance P, NKA, CGRP).
  • These neuropeptides induce smooth muscle contraction, edema, mucus hypersecretion, and inflammation.

    • Conclusions:

    • Axon reflexes are a significant contributor to asthma pathophysiology.
    • Targeting axon reflexes offers potential for novel asthma therapies.