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A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

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Stroke in essential thrombocythemia.

Éva Pósfai¹, Imelda Marton¹, Anita Szőke¹

¹2nd Department of Medicine and Cardiology Center, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary.

Journal of the Neurological Sciences

|November 5, 2013

Summary

Essential thrombocythemia (ET) increases stroke risk, particularly small-vessel ischemic types. Early diagnosis and personalized vascular risk management in ET patients are crucial for preventing cerebrovascular events.

Keywords:

Cerebrovascular events Essential thrombocythemia JAK2 V617F mutation Myeloproliferative neoplasm Platelets Risk factors Stroke

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Area of Science:

Neurology
Hematology
Vascular Medicine

Background:

Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by elevated platelet counts.
Stroke is a severe complication that can arise in patients with ET.
Understanding the incidence and characteristics of stroke in ET patients is critical for patient management.

Purpose of the Study:

To determine the incidence of stroke in patients diagnosed with essential thrombocythemia.
To investigate the specific characteristics and risk factors associated with stroke in this patient population.
To identify potential strategies for preventing cerebrovascular events in ET patients.

Main Methods:

A retrospective analysis of 102 patients with essential thrombocythemia diagnosed between 1999 and 2012.
Selection of patients who experienced one or more stroke events.
Review of stroke event characteristics, medication use, platelet counts, and vascular risk factors.

Main Results:

Eleven ET patients (7% of the cohort) experienced stroke, with a median age of 67 years.
Most stroke patients (82%) had at least two major vascular risk factors.
Brain imaging revealed lacunes or white matter ischemic lesions; no correlation was found between platelet count and stroke occurrence.

Conclusions:

Essential thrombocythemia should be considered a risk factor for stroke, predominantly small-vessel ischemic type.
Early diagnosis and personalized management of global vascular risk are essential for preventing cerebrovascular events in ET.
Comprehensive risk factor assessment and management are vital for ET patients to mitigate stroke risk.