Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pneumonia I: Introduction01:29

Pneumonia I: Introduction

58
Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
58
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

1.5K
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
1.5K
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

150
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
150
Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

197
The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
197
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

4.7K
The pathophysiology of pneumonia involves the following steps:
4.7K
Atypical Pneumonia01:14

Atypical Pneumonia

88
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
88

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immature teratoma of the ovary in children and adolescents: A multi-institutional study of characteristics and management.

Gynecologic oncology·2026
Same author

Immature teratoma of the ovary with microscopic yolk sac tumor in children and adolescents: A multi-institutional study.

Gynecologic oncology·2026
Same author

Age at time of surgery does not influence outcome in idiopathic normal pressure hydrocephalus - a national quality registry study of 3082 patients.

Acta neurochirurgica·2025
Same author

Public health issues and health rendezvous for migrants from conflict zones in Ukraine: A French practice guideline.

Infectious diseases now·2022
Same author

[Gestion of arboviral alerts: Experience feedback from the Secproch working group of the French "Haut Conseil de la santé publique" (2019-2021)].

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2021
Same author

Tolerance and microbiological efficacy of cefepime or piperacillin/tazobactam in combination with vancomycin as empirical antimicrobial therapy of prosthetic joint infection: a propensity-matched cohort study.

The Journal of antimicrobial chemotherapy·2020

Related Experiment Video

Updated: May 6, 2026

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives
10:26

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives

Published on: June 15, 2020

10.6K

[Staphylococcus aureus broncho-pulmonary infections].

F Valour1, N Chebib2, Y Gillet3

  • 1Service des maladies infectieuses et tropicales, hospices civils de Lyon, hôpital de la Croix-Rousse, groupement hospitalier Nord, 103, Grande-Rue-de-la-Croix-Rousse, 69004 Lyon, France; Université Claude-Bernard Lyon 1, 69008 Lyon, France; Inserm U1111, CNRS UMR5308, ENS de lyon, UCBL1, Centre international de recherche en infectiologie (CIRI), 69007 Lyon, France; Centre national de référence des staphylocoques, hospices civils de Lyon, 69008 Lyon, France.

Revue De Pneumologie Clinique
|November 5, 2013
PubMed
Summary

Staphylococcus aureus causes community-acquired pneumonia, especially in the elderly, and severe necrotizing pneumonia in young individuals. Treatment for S. aureus pneumonia involves high-dose antibiotics and, in severe cases, intravenous immunoglobulin.

Keywords:
Broncho-pulmonary infectionHospital-acquired pneumoniaLeucocidine de Panton-ValantinePanton-Valentin leukocidinPneumopathiePneumopathie nococomialeStaphylococcus aureus

More Related Videos

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

23.0K
Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

14.7K

Related Experiment Videos

Last Updated: May 6, 2026

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives
10:26

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives

Published on: June 15, 2020

10.6K
Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

23.0K
Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

14.7K

Area of Science:

  • Bacteriology
  • Pulmonology
  • Infectious Diseases

Context:

  • Staphylococcus aureus is a significant cause of pneumonia, ranging from community-acquired to hospital-acquired infections.
  • Specific strains producing Panton-Valentine leukocidin are linked to severe necrotizing pneumonia, particularly in young individuals after influenza.
  • Methicillin resistance in S. aureus is a critical factor in cystic fibrosis and hospital-acquired pneumonia outcomes.

Purpose:

  • To outline the role of Staphylococcus aureus in various pneumonia types.
  • To describe the clinical presentation and treatment strategies for S. aureus pneumonia.
  • To highlight the impact of antibiotic resistance and specific toxins on pneumonia severity and outcomes.

Summary:

  • Staphylococcus aureus accounts for 2-5% of community-acquired pneumonia, primarily in elderly patients with comorbidities or following viral infections.
  • Necrotizing pneumonia, associated with Panton-Valentine leukocidin, affects young individuals and carries a high mortality rate (50%), requiring high-dose anti-staphylococcal penicillin, clindamycin, and potentially intravenous immunoglobulin.
  • In hospital-acquired pneumonia, S. aureus is common (20-30%), often methicillin-resistant, necessitating glycopeptides or linezolid.

Impact:

  • Understanding S. aureus's diverse roles in pneumonia is crucial for timely diagnosis and effective treatment.
  • Identifying toxin-producing strains and antibiotic resistance patterns guides therapeutic decisions and improves patient outcomes.
  • Further research is needed to define the role of newer antibiotics in managing resistant S. aureus pneumonia.