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Updated: May 6, 2026
Competitive Homing Assays to Study Gut-tropic T Cell Migration
Published on: March 1, 2011
A mechanism for selective lymphocyte homing in bovine hemal nodes
Weidong Zhang1, Tetsuo Nasu, Masahiro Yasuda
1Department of Veterinary Anatomy, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen Kibanadai-Nishi, Miyazaki 889-2192, Japan.
Abstract:
The distribution and abundance of MECA-79(+) cells in bovine hemal nodes (HNs) was analyzed. In addition, T cell subsets which expressed the homing receptor l-selectin were analyzed by flow cytometry. The frequency of MECA-79(+) HNs varied depending on the location. There were 61, 33, and 17% MECA-79(+) HN in the subcutaneous region, along the abdominal aorta and in the mesenteric region, respectively. MECA-79(+) cells in mesenteric lymph nodes were mainly distributed in the paracortex. Many MECA-79(+) cells were distributed in the perifollicular area of HNs and a few positive cells were also located in the paracortical and interfollicular areas. CD4(+) and CD8(+)l-selectin(+) cells were significantly higher in MECA-79(+) HNs compared to MECA-79(-) HNs. The data suggest that a selective lymphocyte homing mechanism exists in bovine HNs, which could be related to functional differences between locations.
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