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Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian
Michael K Lo1, Brian H Bird1, Anasuya Chattopadhyay2
1Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States.
Abstract:
Nipah virus (NiV) continues to cause outbreaks of fatal human encephalitis due to spillover from its bat reservoir. We determined that a single dose of replication-defective vesicular stomatitis virus (VSV)-based vaccine vectors expressing either the NiV fusion (F) or attachment (G) glycoproteins protected hamsters from over 1000 times LD50 NiV challenge. This highly effective single-dose protection coupled with an enhanced safety profile makes these candidates ideal for potential use in livestock and humans.
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