Determinants of nocturia: the Krimpen study
Boris van Doorn1, Esther T Kok1, Marco H Blanker2
1Department of Urology, University Medical Center Utrecht, Utrecht, The Netherlands.
The Journal of Urology
|November 5, 2013
Summary
In older men, smaller maximum voided volume, lower urinary tract symptoms, and polyuria are linked to nocturia. These factors may be modifiable, offering potential treatment targets for frequent nighttime urination.
Area of Science:
- Urology
- Geriatrics
- Epidemiology
Background:
- Nocturia is a common condition in older adults.
- Previous studies identified cross-sectional associations with nocturia.
- Longitudinal associations using frequency-volume charts remain understudied.
Purpose of the Study:
- To identify modifiable determinants of nocturia in older men.
- To investigate longitudinal associations with nocturia using frequency-volume charts.
- To analyze factors contributing to nocturia in a community-based cohort.
Main Methods:
- A longitudinal study of 1,688 men aged 50-78 years with 6-year follow-up.
- Data collected via frequency-volume charts, medical exams, and questionnaires.
- Nocturia defined as ≥2 voids/night; polyuria defined by 24-hour volume and nocturnal production rates.
Main Results:
- Age, reduced maximum voided volume, 24-hour polyuria, and nocturnal polyuria (both definitions) were associated with increased nocturia.
- Lower urinary tract symptoms also showed a longitudinal association with nocturia.
- Specific age groups (50-55 vs. >60 years) and voided volumes (<300 ml) were significant predictors.
Conclusions:
- Smaller maximum voided volume, lower urinary tract symptoms, and polyuria are significant, potentially modifiable determinants of nocturia.
- Nocturnal polyuria, assessed by two definitions, independently predicts nocturia.
- Findings suggest a possible two-step etiologic process for nocturnal polyuria.
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