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Morphine modifies the cingulate-operculum network underlying painful rectal evoked potentials.

D Lelic1, A E Olesen1, H Gregersen2

  • 1Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Mølleparkvej 4, DK-9000 Aalborg, Denmark.

Neuropharmacology
|November 5, 2013
PubMed
Summary
This summary is machine-generated.

Morphine alters brain networks involved in rectal pain, showing a shift in the cingulate cortex that correlates with reduced pain perception. This brain network reorganization may serve as a biomarker for opioid effectiveness.

Keywords:
Experimental painMorphineMultichannel matching pursuitRectal evoked potentialsSource localization

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Area of Science:

  • Neuroscience
  • Pain Research
  • Pharmacology

Background:

  • The impact of opioids on brain networks processing visceral pain is largely unexplored.
  • Rectal evoked potentials (EPs) offer a method to study brain responses to rectal stimulation.

Purpose of the Study:

  • To investigate how morphine affects brain network connectivity underlying rectal evoked potentials (EPs).
  • To determine if changes in brain networks correlate with subjective pain scores after morphine administration.

Main Methods:

  • A placebo-controlled, cross-over study involving 20 healthy volunteers.
  • Measurement of sensory and pain thresholds, rectal EPs (62-channel), and subjective pain ratings before and after placebo/morphine (30 mg).
  • Brain source connectivity analysis of EPs.

Main Results:

  • Morphine significantly increased sensory and pain thresholds.
  • While placebo reduced pain scores by 14.5%, morphine attenuated them by 37.5%.
  • EP amplitudes remained stable with morphine, unlike placebo which showed a 33.9% reduction. A cingulate-operculum network dominated rectal pain processing, with morphine causing an anterior shift in the cingulate source, correlating with pain reduction.

Conclusions:

  • Visceral pain relief from morphine is linked to reorganization within the cingulate cortex.
  • This cingulate cortex reorganization may serve as a potential biomarker for assessing opioid effects on pain.