Related Experiment Video

Updated: May 6, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

26.7K

Bisphenol A and cardiometabolic risk factors in obese children

Naila Khalil1, James R Ebert2, Lei Wang3

  • 13123 Research Blvd, Suite #200, Center for Global Health, Department of Community Health, Boonshoft School of Medicine, Wright State, University, Dayton, OH, USA.

The Science of the Total Environment
|November 5, 2013
PubMed

Insights

Bisphenol-A (BPA) exposure in obese children, particularly males, is linked to adverse liver and metabolic health effects. This study investigated the association between BPA and non-alcoholic fatty liver disease (NAFLD) in children.

Area of Science:

  • Environmental health
  • Pediatric endocrinology
  • Hepatology

Background:

  • Bisphenol-A (BPA) is an endocrine disruptor linked to obesity and liver changes.
  • Non-alcoholic fatty liver disease (NAFLD) is prevalent in obese US children.
  • The relationship between BPA and pediatric NAFLD is not well understood.

Purpose of the Study:

  • To investigate the potential role of BPA in the development of NAFLD in children.
  • To examine the association between urinary BPA levels and metabolic/liver markers in obese and overweight children.

Main Methods:

  • Cross-sectional study of 39 obese/overweight children (3-8 years).
  • Anthropometric, clinical, and biochemical assessments were performed.
  • Urinary BPA was measured using LC-MS/MS and adjusted for creatinine.

Main Results:

  • Elevated urinary BPA (creatinine) correlated with higher free thyroxine.
  • In males, BPA (creatinine) was associated with increased aspartate aminotransferase and diastolic blood pressure.
  • BPA was linked to insulin resistance markers (fasting insulin, HOMA-IR) in males, showing a non-monotonic relationship.

Conclusions:

  • Urinary BPA is associated with adverse liver and metabolic outcomes in obese children, especially males.
  • Findings suggest BPA may contribute to liver and metabolic disturbances in this population.
  • Further research is warranted to confirm these associations and explore mechanisms.
Abstract

Keywords:
Bisphenol AChildhood obesityEndocrine disruptorNon-monotonic dose responseNonalcoholic fatty liver diseaseSpline analysis

More Related Videos

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.7K
Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography13:09

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

17.5K

Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
448
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.6K
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
332
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
374
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
417
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
2.1K