Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurulation01:30

Neurulation

40.4K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
40.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drug related adverse events due to cardiotropic agents : Epidemiology and prognosis in the emergency department.

La Tunisie medicale·2019
Same author

Radiology quiz.

Neurosciences (Riyadh, Saudi Arabia)·2013
Same author

[Volvulus of the small intestine in adults: CT diagnostic of polysplenia syndrome].

Gastroenterologie clinique et biologique·2008
Same author

Hepatic hydatid cyst with fat-fluid level and Budd-Chiari syndrome.

Annals of Saudi medicine·2007
Same author

What's your diagnosis? Subserosal uterine lipoleiomyoma fortuitously associated with endometrial carcinoma.

Annals of Saudi medicine·2007
Same author

Giant abdominal cystic textiloma mimicking hydatid cyst.

Annals of Saudi medicine·2007

Related Experiment Video

Updated: May 6, 2026

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

1.8K

An infant with isolated Lissencephaly.

S Jouini1, A S Al-Awashiz, G I Izoura

  • 1Northern Area Armed Forces Hospital, Hafr Al-Batin, Kingdom of Saudi Arabia.

Neurosciences (Riyadh, Saudi Arabia)
|November 5, 2013
PubMed
Summary

Lissencephaly, a brain malformation due to neuronal migration disorders, causes a smooth brain surface. This case highlights severe intellectual impairment, seizures, and evolving spasticity in an infant.

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • Lissencephaly (agyria) is a rare brain malformation characterized by a smooth cerebral surface, indicating disrupted neuronal migration.
  • It is a hereditary disorder often associated with significant neurological deficits.

Purpose of the Study:

  • To present a case of isolated lissencephaly in an infant.
  • To detail the associated clinical features and disease progression.

Main Methods:

  • Case report of an infant diagnosed with isolated lissencephaly.
  • Clinical observation and assessment of neurological features.

Main Results:

  • The infant presented with profound intellectual impairment, seizures, and hypotonia.

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

10.5K
Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

15.6K

Related Experiment Videos

Last Updated: May 6, 2026

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

1.8K
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

10.5K
Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

15.6K
  • Hypotonia evolved into spasticity by the second year of life.

    • Conclusions:

    • Isolated lissencephaly presents with severe clinical manifestations including developmental delay and motor deficits.
    • High morbidity and mortality are associated with lissencephaly, often dependent on accompanying complications.