Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Neuropathy01:22

Diabetic Neuropathy

99
DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
99
Diabetic Nephropathy01:28

Diabetic Nephropathy

52
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
52
Diabetic Retinopathy01:27

Diabetic Retinopathy

66
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
66
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

45
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
45
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

122
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular...
122
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.9K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacological characterization of GT-2016, a non-thiourea-containing histamine H3 receptor antagonist: in vitro and in vivo studies.

The Journal of pharmacology and experimental therapeutics·1995
Same author

Clinicopathological features and management of immunoproliferative small intestinal disease and primary small intestinal lymphoma in Pakistan.

Medical and pediatric oncology·1995
Same author

The role of dose rate in the induction of micronuclei in deep-lung fibroblasts in vivo after exposure to cobalt-60 gamma rays.

Radiation research·1995
Same author

Efficacy of ciprofloxacin in enteric fever: comparison of treatment duration in sensitive and multidrug-resistant Salmonella.

The American journal of tropical medicine and hygiene·1995
Same author

Atrial arrhythmias and pacing after orthotopic heart transplantation: bicaval versus standard atrial anastomosis.

British heart journal·1995
Same author

Nutritional evaluation of desi and kabuli chickpeas and their products commonly consumed in Pakistan.

International journal of food sciences and nutrition·1995
Same journal

Association Between Extracranial Artery Stenosis and Cerebral Small-Vessel Disease in Patients with Ischemic Stroke.

Neurosciences (Riyadh, Saudi Arabia)·2026
Same journal

Identifying Risk Factors for the Rising Prevalence of Multiple Sclerosis in Saudi Arabia: A case-control analysis.

Neurosciences (Riyadh, Saudi Arabia)·2026
Same journal

Novel <i>ENPP</i>1 Gene Mutation Causing Generalized Arterial Calcification of Infancy: A case report.

Neurosciences (Riyadh, Saudi Arabia)·2026
Same journal

Insights Into Stroke Risk and Prediction for Underweight Individuals.

Neurosciences (Riyadh, Saudi Arabia)·2026
Same journal

Key Attributes of an Ideal Neurology Residency Candidate: Program Directors' Perspectives.

Neurosciences (Riyadh, Saudi Arabia)·2026
Same journal

Impact of Burnout and Sleep Deprivation on the Clinical Performance of Neurology Residents: A Cross-Sectional Country Wide Study.

Neurosciences (Riyadh, Saudi Arabia)·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
05:06

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

2.6K

Diabetic neuroarthropathy.

S A Qidawi1, M A Khan, S R Hussain

  • 1King Khalid Hospital, Najran, Kingdom of Saudi Arabia.

Neurosciences (Riyadh, Saudi Arabia)
|November 5, 2013
PubMed
Summary
This summary is machine-generated.

Diabetic neuroarthropathy affects 4% of patients with diabetes and neuropathy, commonly involving foot joints. Early detection via imaging is crucial to prevent severe complications.

More Related Videos

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

5.9K
Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

1.2K

Related Experiment Videos

Last Updated: May 6, 2026

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
05:06

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

2.6K
Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

5.9K
Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

1.2K

Area of Science:

  • Orthopedics
  • Endocrinology
  • Radiology

Background:

  • Diabetic neuroarthropathy is an under-recognized complication of diabetes mellitus.
  • Peripheral neuropathy is a common comorbidity in long-standing, poorly controlled diabetes.

Purpose of the Study:

  • To determine the incidence of diabetic neuroarthropathy and associated morbidity in diabetic patients.
  • To evaluate clinical and radiographic findings indicative of diabetic neuroarthropathy.

Main Methods:

  • Retrospective analysis of 296 diabetic patients' medical records (June 1998 - July 1999).
  • Clinical assessment for neuropathy (absent ankle jerk, sensory loss) and radiographic evaluation for arthropathic changes.
  • Treatment included conservative (total contact casting) and surgical (excision, amputation) methods.

Main Results:

  • Diabetic neuropathy was present in 12.5% of patients; 4% (11 patients) had diabetic neuroarthropathy.
  • Commonly affected joints included tarsometatarsal (76%), metatarsophalangeal (59%), subtalar (47%), and interphalangeal (41%).
  • Total contact casting showed satisfactory progress; two patients required amputation.

Conclusions:

  • Diabetic neuroarthropathy requires increased attention, particularly in Saudi Arabia.
  • Routine radiography or CT scans are recommended for high-risk diabetic feet.
  • Timely diagnosis can prevent severe, debilitating complications.