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Updated: May 6, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Bone preservation in dehiscence-type defects using composite biphasic calcium sulfate plus biphasic
Eli E Machtei1, Doron Rozitsky, Hadar Zigdon-Giladi
1*Professor and Chairman, Department of Periodontology, Rambam HCC School of Graduate Dentistry, and Faculty of Medicine, Technion (Israel Institute of Technology), Haifa, Israel; Visiting Associate Professor, Division of Periodontology, Department of Oral Medicine, Infection and Immunity, Harvard Faculty of Dental Medicine, Boston, MA. †Resident, Department of Periodontology, Rambam HCC School of Graduate Dentistry, and Faculty of Medicine, Technion (Israel Institute of Technology), Haifa, Israel. ‡Head, Mineralized Tissue Laboratory, Department of Periodontology, Rambam HCC School of Graduate Dentistry, and Faculty of Medicine, Technion (Israel Institute of Technology), Haifa, Israel. §Senior Lecturer, Department of Periodontology, Rambam HCC School of Graduate Dentistry, and Faculty of Medicine, Technion (Israel Institute of Technology), Haifa, Israel.
Objectives:
To examine bone formation in dehiscence defects using biphasic hydroxyapatite/β-tricalcium phosphate plus biphasic calcium sulfate (BCP/BCS).
Material:
After extractions, 24 mandibular buccal dehiscence defects (3 × 3 mm) were treated with BCP/BCS (E), membrane (MC), or control (NC). Histology and histomorphometric analysis were performed.
Results:
After 6 weeks, bone formation was noticeable in most sites. In subsequent phases, the woven bone was gradually remodeled into lamellar bone and marrow. Vertical new bone height in the E and MC groups (1.06 and 0.85 mm.) was substantially greater than that in the NC group (-0.28 mm). For all groups, there was an overall increase in the height of the newly formed bone through the observation. At week 12, the vertical bone height was 1.95, 2.07, and 0.29 mm, respectively. The mean new bone area in the E and MC groups was much greater than that in the NC group (2.85, 2.80, and -0.20 mm, respectively). Percent new bone in all 3 groups was similar (36.25%, 34.84%, and 28.34%, respectively).
Conclusions:
This study demonstrates the efficacy of BCP/BCS graft for bone augmentation in dehiscence-type extraction socket defect.
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