Related Experiment Video
Updated: May 6, 2026

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
Effects of thyroidectomy on the storage of organochlorine insectisides
M Wassermann1, D Wassermann, S Lazarovici
1Department of Occupational Health, The Hebrew University, Hadassah Medical School, Jerusalem.
Abstract:
Rats submitted to p,p'-DDT at 200 ppm in drinking water showed increased p, p'-DDT storage which was not statistically different from that of thyroidectomized rats receiving p, p'-DDT. Rats receiving p, p'-DDT also showed increased fat storage of total o, p'-DDT and Dieldrin and decreased total BHC storage.Thyroidectomy decreased the amount of p, p'-DDT naturally occurring in the animal body and raised the metabolization of this compound.In thyroidectomized rats submitted to the same dosage of p, p'-DDT, increased storage of p, p'-DDT, o, p'-DDT and Dieldrin was found. A statistically significant increase in BHC was also observed.It is concluded that p, p'-DDT in the diet may affect the storage level of other organochlorine insecticides depending on its concentration, and that the physiopathological state of the body, e. g. thyroidectomy has a definite influence on the storage of organochlorine insecticides in the animal body and on their biological effect.
Related Concept Videos
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Hyperthyroidism II: Pathophysiology
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Hyperthyroidism I: Introduction
Goiter

