GWIPS-viz: development of a ribo-seq genome browser

Area of Science:

• Molecular Biology
• Genomics
• Bioinformatics

Background:

• Ribosome profiling (ribo-seq) is a technique to quantify ribosome density across mRNA transcripts, providing genome-wide information on protein synthesis (GWIPS) in vivo.
• The increasing application of ribo-seq across various organisms necessitates a centralized platform for data visualization and analysis.

Purpose of the Study:

• To develop and present GWIPS-viz, a dedicated online genome browser for ribosome profiling data.
• To facilitate the accessibility and interpretation of ribo-seq datasets for the scientific community.

Main Methods:

• Development of GWIPS-viz, an online genome browser built upon the UCSC Genome Browser framework.
• Integration of ribo-seq and mRNA-seq tracks for multiple species, including human, mouse, zebrafish, yeast, and bacteria.
• Inclusion of data from published ribo-seq studies.

Main Results:

• GWIPS-viz provides a user-friendly interface for visualizing genome-wide ribosome profiling data.
• Ribo-seq and mRNA-seq data tracks are available for diverse organisms, enabling comparative analyses.
• The browser supports visualization of ribosome density across mRNA transcripts.

Conclusions:

• GWIPS-viz addresses the growing demand for a specialized ribo-seq data visualization tool.
• The platform aims to streamline the analysis of protein synthesis at a genome-wide scale.
• Continued incorporation of new ribo-seq datasets will enhance its utility for the research community.