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Related Experiment Video

Updated: May 6, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

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Published on: November 15, 2013

[Not Available].

N Drescher¹, T F Burger

¹Landwirtschaftliche Versuchsstation, BASF, 6703, Limburgerhof, Pfalz.

Bulletin of Environmental Contamination and Toxicology

|November 5, 2013

Summary

This summary is machine-generated.

Microorganisms in soil can efficiently dephenylate the herbicide pyrazon (5-amino-4-chloro-2-phenyl-3(2H)-pyridazinone), producing a pure radioactive metabolite. This microbial process offers a cost-effective synthesis route for the labeled compound.

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Area of Science:

Environmental chemistry
Microbiology
Biochemical synthesis

Context:

The herbicide pyrazon (5-amino-4-chloro-2-phenyl-3(2H)-pyridazinone) is degraded in soil.
Microbial communities in soil can be conditioned to enhance pyrazon degradation.
Chemical synthesis of the radiolabeled metabolite is challenging and expensive.

Purpose:

To synthesize 5-amino-4-chloro-3(2H)-pyridazinone-(4,5-(14)C) using microbiological dephenylation.
To establish a cost-effective method for producing the radiolabeled metabolite.
To investigate the microbial degradation pathway of pyrazon in conditioned soil.

Summary:

Soil microorganisms were utilized to dephenylate pyrazon-(4,5-(14)C), yielding 5-amino-4-chloro-3(2H)-pyridazinone-(4,5-(14)C).
Conditioned soils demonstrated high degradation capacity, metabolizing up to 5000 ppm pyrazon within 14 days.
The microbiological synthesis resulted in a 53.1% recovery of the pure, radiolabeled metabolite.

Impact:

Provides a viable and economical method for synthesizing radiolabeled pyrazon metabolites.
Highlights the potential of tailored microbial consortia for bioremediation and synthesis.
Facilitates further research into the environmental fate and metabolism of pyrazon.