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Plasma membrane guanylate cyclase is a multimodule transduction system
R K Sharma1, T Duda, A Sitaramayya
1The Unit of Regulatory and Molecular Biology, Pennsylvania College of Optometry, 1200 West Godfrey Avenue, 19141, Philadelphia, Pennsylvania, USA.
Abstract:
This minireview highlights the studies which suggest that guanylate cyclase is a single-component transducing system, containing distinct signaling modules in a single membrane-spanning protein. A guanylate cyclase signaling model is proposed which envisions the following sequential events: (1) a signal is initiated by the binding of the hormone to the ligand binding module; (2) the signal is potentiated by ATP at ARM; and (3) the amplified signal is finally transduced at the catalytic site. All of these signaling steps together constitute a switch, which when turned on, generates the second messenger cyclic GMP.
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