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Updated: May 6, 2026

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR
Published on: July 11, 2025
Variation of crossover association frequencies with various aberrant segregation classes in Ascobolus
1Laboratoire de Biologie Cellulaire et Génétique, Bat. 400, Université Paris-Sud, 91405, Orsay Cedex, France.
Abstract:
1710 asci exhibiting mendelian or aberrant segregation at the b8 spore colour locus in Ascobolus were analysed from crosses between b8 mutants and the wild type in the presence of linked flanking markers. The frequencies of associated crossing-over were found to vary with the various classes of aberrant segregation and thus for the same allele. The highest crossover associations were found for aberrant 4+4m octads (close to 50%), the lowest for 5:3 post-meiotic segregations (19%), whereas 6:2 octads exhibited intermediary values. These variations are interpreted with respect to the modalities of hybrid DNA distribution (asymmetrical versus symmetrical), and mismatch correction.
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