[Effect of prior oral antigen administration on the immune response to parenterally applied antigen in mice]

Feeding of sheep red blood cells (SRBC) and HGG over a period of 10 days leads to production of serum antibodies. Simultaneously the mice become a status of sensitization to a second systemic immunization. The number of anti SRBC-Plaque forming cells decreases in the spleen however. Under the influence of SRBC-feeding the rosette forming cells (RFC) increases in the Peyer's patches. This high level of RFC is transient only.