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Related Concept Videos

Gene Conversion02:08

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Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
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Surface replacement conversion: results depend upon reason for revision.

E P Su1, S L Su

  • 1Hospital for Special Surgery, 535 East 70th Street, New York, New York 10021, USA.

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|November 5, 2013
PubMed
Summary
This summary is machine-generated.

Revision of surface hip replacement (SHR) yields good clinical outcomes, particularly when addressing mechanical issues. Early intervention is key to managing potential complications and ensuring favorable results for selected patients.

Keywords:
Hip resurfacingOutcomesRevision hipSurface replacement conversion

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Area of Science:

  • Orthopedic Surgery
  • Biomaterials Science
  • Reconstructive Surgery

Background:

  • Surface hip replacement (SHR) offers bone preservation benefits for active patients.
  • Assessing the long-term success of SHR revisions is crucial for its continued clinical application.

Purpose of the Study:

  • To evaluate the clinical outcomes of surface hip replacement revisions.
  • To identify factors influencing revision success and guide future patient selection.

Main Methods:

  • Retrospective review of 55 SHR revisions between 2007 and 2012.
  • Analysis of revision types, etiologies, and post-operative Harris hip scores (HHS).

Main Results:

  • Mean post-operative HHS was 94.8 at 2.3 years follow-up.
  • Mechanical reasons (23) and metallosis (13) were common revision causes.
  • Lower HHS noted in revisions for unexplained pain versus mechanical reasons (p=0.029).

Conclusions:

  • Revision of SHR can achieve good to excellent results in selected patients.
  • Close monitoring and early intervention are recommended for SHR patients.
  • A low threshold for revision is advised for component malposition, elevated metal ions, or soft-tissue abnormalities.