Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

335
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
335
Distributions to Estimate Population Parameter01:26

Distributions to Estimate Population Parameter

4.5K
The accurate values of population parameters such as population proportion, population mean, and population standard deviation (or variance) are usually unknown. These are fixed values that can only be estimated from the data collected from the samples. The estimates of each of these parameters are sample proportion, the sample mean, and sample standard deviation (or variance). To obtain the values of these sample statistics, data are required that have particular distribution and central...
4.5K
Poisson Probability Distribution01:09

Poisson Probability Distribution

10.1K
A Poisson probability distribution is a discrete probability distribution. It gives the probability of a number of events occurring in a fixed interval of time or space if these events happen at a known average rate and independently of the time since the last event. For example, a book editor might be interested in the number of words spelled incorrectly in a particular book. It might be that, on average, there are five words spelled incorrectly in 100 pages. The interval is 100 pages.
The...
10.1K
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

1.5K
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
1.5K
Binomial Probability Distribution01:15

Binomial Probability Distribution

13.2K
A binomial distribution is a probability distribution for a procedure with a fixed number of trials, where each trial can have only two outcomes.
The outcomes of a binomial experiment fit a binomial probability distribution. A statistical experiment can be classified as a binomial experiment if the following conditions are met:
There are a fixed number of trials. Think of trials as repetitions of an experiment. The letter n denotes the number of trials.
There are only two possible outcomes,...
13.2K
Applications of Integration to Probability Density Functions01:27

Applications of Integration to Probability Density Functions

201
Continuous probability distributions are used to model random variables that can take on any real value within a specified range. These variables do not take on isolated or countable values but rather exist on a continuum. For example, the height of an individual can be measured with increasing precision—such as 163.5 or 165.25 centimeters—demonstrating that height is a continuous random variable.The behavior of such variables is described using a probability density function (PDF),...
201

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sequential Gibbs posteriors with applications to principal component analysis.

Biometrika·2026
Same author

Scalable and robust regression models for continuous proportional data.

Journal of the American Statistical Association·2026
Same author

Local graph estimation with pathwise false discovery control.

Nature communications·2026
Same author

Regression Analysis of Arbitrarily Censored and Left-Truncated Data Under the Proportional Odds Model.

Biometrical journal. Biometrische Zeitschrift·2026
Same author

Is ambulatory flexible ureteroscopic lithotripsy safe and feasible? evidence from a propensity score-matched cohort.

BMC urology·2026
Same author

IVUS or Angiography Guidance for Percutaneous Coronary Intervention in Complex Coronary Bifurcation Lesions: The DKCRUSH VIII Randomized Clinical Trial.

Journal of the American College of Cardiology·2026
Same journal

Probabilistic Joint and Individual Variation Explained (ProJIVE) for Data Integration.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

fastkqr: A Fast Algorithm for Kernel Quantile Regression.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Empirical Bayes Covariance Decomposition, and a Solution to the Multiple Tuning Problem in Sparse PCA.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Joint Registration and Conformal Prediction for Partially Observed Functional Data.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Efficient Decision Trees for Tensor Regressions.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Distributed Nonparametric Regression with Heterogeneity Through Prediction-Based Aggregation.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
12:39

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

Published on: December 10, 2012

10.6K

Fast Bayesian Inference in Dirichlet Process Mixture Models.

Lianming Wang1, David B Dunson

  • 1Department of Statistics, University of South Carolina, Columbia, SC 29208.

Journal of Computational and Graphical Statistics : a Joint Publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America
|November 5, 2013
PubMed
Summary
This summary is machine-generated.

This study introduces a fast algorithm for Dirichlet process mixture (DPM) models, addressing limitations of Markov chain Monte Carlo (MCMC) in large datasets. The novel approach enables efficient Bayesian nonparametric inference and model comparison.

Keywords:
ClusteringDensity estimationEfficient computationLarge samplesNonparametric BayesPólya urn schemeSequential analysis

More Related Videos

A Tactile Automated Passive-Finger Stimulator TAPS
19:44

A Tactile Automated Passive-Finger Stimulator TAPS

Published on: June 3, 2009

14.9K
A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
08:12

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

Published on: March 1, 2022

2.1K

Related Experiment Videos

Last Updated: May 6, 2026

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
12:39

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

Published on: December 10, 2012

10.6K
A Tactile Automated Passive-Finger Stimulator TAPS
19:44

A Tactile Automated Passive-Finger Stimulator TAPS

Published on: June 3, 2009

14.9K
A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
08:12

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

Published on: March 1, 2022

2.1K

Area of Science:

  • Statistics
  • Machine Learning
  • Computational Statistics

Background:

  • Bayesian nonparametric methods are gaining traction for large, high-dimensional data.
  • Current Markov chain Monte Carlo (MCMC) algorithms are often computationally infeasible for these settings.
  • Faster algorithms are crucial for practical application of Bayesian nonparametric methods.

Purpose of the Study:

  • To propose a fast algorithm for inference in Dirichlet process mixture (DPM) models.
  • To enable efficient model selection and comparison between parametric and nonparametric alternatives.
  • To provide a computationally tractable approach for large-scale Bayesian nonparametric analysis.

Main Methods:

  • A sequential greedy search algorithm is proposed for cluster partitioning, treating it as a model selection problem.
  • Utilizing conjugate priors allows for closed-form posteriors conditional on the selected partition.
  • The approach facilitates Bayes factor testing of parametric versus nonparametric models.

Main Results:

  • The proposed algorithm demonstrates efficiency in simulation studies compared to existing fast nonparametric methods.
  • The method was successfully applied to three real-world datasets, including a large epidemiologic study.
  • Matlab code is provided for reproducibility of simulations and data analyses.

Conclusions:

  • The developed sequential greedy algorithm offers a computationally efficient alternative for DPM model inference.
  • This method enhances the practical applicability of Bayesian nonparametric approaches in large and high-dimensional data scenarios.
  • The ability to perform model comparison using Bayes factors adds significant value for data analysis.