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Are there height-dependent differences in subclinical vascular disease in hypertensive patients?

Caterina Ferriol1, Susanna Tremols, Carmen Jimenez

  • 1PCC Anglès, IAS, Girona, Spain.

Journal of Clinical Hypertension (Greenwich, Conn.)
|November 6, 2013
PubMed

Insights

Height influences subclinical vascular disease (SVD) in hypertensive patients. Taller individuals show increased left ventricular hypertrophy, while shorter individuals exhibit greater microvascular changes, highlighting height as a factor in SVD detection.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Hypertension Research

Background:

  • Subclinical vascular disease (SVD) is a precursor to cardiovascular events.
  • Hypertension is a major risk factor for SVD.
  • The relationship between patient height and SVD in hypertensive individuals is not well-defined.

Purpose of the Study:

  • To investigate potential differences in subclinical vascular disease (SVD) among hypertensive patients based on their height.
  • To identify specific SVD markers associated with varying height quartiles in newly diagnosed, treatment-naive hypertensive patients.

Main Methods:

  • A cohort of 922 newly diagnosed, treatment-naive hypertensive patients was analyzed.
  • Data collection included physical examination, renal function tests, electrocardiography, and retinography.
  • Multivariate analysis adjusted for age, sex, and body mass index was employed.

Main Results:

  • Height above the mean correlated with higher fasting glucose, triglycerides, and left ventricular hypertrophy (LVH).
  • Taller stature was associated with increased odds of LVH (OR, 1.57).
  • Shorter stature showed an inverse association with the arteriole-to-venule ratio (OR, 0.97), suggesting increased microvascular involvement.

Conclusions:

  • Significant differences in SVD exist in hypertensive patients concerning height.
  • Tall stature is linked to LVH, whereas short stature is associated with increased microvascular disease.
  • Height should be considered a factor in the detection and assessment of SVD in hypertensive populations.

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