Related Experiment Video

Updated: May 6, 2026

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing
08:19

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing

Published on: July 7, 2020

9.8K

Which antibiotic for resistant Gram-positives, and why?

John S Bradley1

  • 1University of California, San Diego, School of Medicine, Rady Children's Hospital, San Diego, USA.

The Journal of Infection
|November 6, 2013
PubMed

Insights

Gram-positive pathogen resistance, especially Staphylococcus aureus and enterococcus, is a growing clinical issue. Prudent antibiotic use and infection control are vital for future treatment effectiveness.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Clinical Pharmacy

Background:

  • Rising antimicrobial resistance in Gram-positive pathogens poses a significant clinical challenge.
  • Hospital-acquired infections caused by resistant bacteria lead to increased morbidity and mortality.
  • Emerging resistance necessitates the use of less-studied, potentially more toxic empiric therapies.

Purpose of the Study:

  • To discuss resistance mechanisms in Gram-positive pathogens.
  • To review therapeutic options for treating infections caused by resistant strains.
  • To emphasize the importance of prudent antimicrobial use and infection control.

Main Methods:

  • Review of current literature on Gram-positive pathogen resistance.
  • Analysis of resistance mechanisms for existing antimicrobial agents.
  • Discussion of therapeutic strategies for resistant infections.

Main Results:

  • Detailed examination of resistance mechanisms in key Gram-positive pathogens like Staphylococcus aureus and enterococcus.
  • Identification of challenges associated with current treatment options for resistant infections.
  • Highlighting the inevitable development of resistance to new antimicrobial agents.

Conclusions:

  • Antimicrobial resistance is an ancient and evolving challenge.
  • Prudent use of antimicrobial agents is essential for preserving their efficacy.
  • Effective infection control measures are critical to combatting resistant Gram-positive pathogens.
Keywords:
Antibiotic resistanceCeftarolineDaptomycinEnterococcus vancomycin-resistantLinezolidMethicillin-resistantStaphylococcus aureusVancomycin

More Related Videos

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

4.6K
Antibiotic Dereplication Using the Antibiotic Resistance Platform10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

10.6K

Related Concept Videos

Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
251
Inhibitors of Gram-positive Cell Wall Synthesis01:23

Inhibitors of Gram-positive Cell Wall Synthesis

Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...
225
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
2.0K
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
115
Inhibitors of Bacterial Protein Synthesis01:25

Inhibitors of Bacterial Protein Synthesis

Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
127
Antibiotic Selection00:57

Antibiotic Selection

Overview
49.1K