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Multipurpose prevention technologies: products in development.

David R Friend1, Justin T Clark, Patrick F Kiser

  • 1CONRAD Program, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, 1911 N. Fort Myer Drive, Suite 900, Arlington, VA 22209, United States.

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Summary
This summary is machine-generated.

Multipurpose prevention technologies (MPTs) offer combined protection against unintended pregnancy and sexually transmitted infections like HIV-1. Recent advancements in topical antiretrovirals (ARVs) are accelerating the development of these crucial sexual and reproductive health products.

Keywords:
ContraceptionHIV-1 preventionHerpes simplex virus-2 preventionMultipurpose prevention technologies

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Area of Science:

  • Sexual and Reproductive Health
  • Infectious Disease Prevention
  • Pharmaceutical Development

Background:

  • Multipurpose prevention technologies (MPTs) aim to address multiple sexual and reproductive health needs simultaneously.
  • Despite decades of discussion, limited product development has occurred until recently.
  • Proof-of-concept for topical antiretrovirals (ARVs) has revitalized interest in MPTs.

Purpose of the Study:

  • To review the current landscape of MPTs in development.
  • To categorize MPTs into long-acting and on-demand formulations.
  • To highlight the potential benefits and challenges in MPT development.

Main Methods:

  • Categorization of MPTs into long-acting (intravaginal rings, injectables) and on-demand products.
  • Review of specific MPTs in development, including their mechanisms and target conditions.
  • Discussion of technical, funding, and regulatory hurdles.

Main Results:

  • Several long-acting MPTs are in development, including intravaginal rings (IVRs) releasing tenofovir/levonorgestrel or dapivirine/levonorgestrel.
  • Long-acting injectable pre-exposure prophylaxis (PrEP) formulations are also under clinical evaluation.
  • On-demand products include tenofovir (TFV) 1% gel, zinc/carrageenan gel, and diaphragm-based methods.

Conclusions:

  • MPTs offer significant potential benefits for women's health globally.
  • Overcoming technical, funding, and regulatory challenges is crucial for MPT advancement.
  • Continued motivation and investment are needed to bring these vital products to fruition.