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Updated: May 6, 2026

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model
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Telocytes in human oesophagus.

Xiaoke Chen1, Yonghua Zheng, Catalin G Manole

  • 1Department of thoracic surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Journal of Cellular and Molecular Medicine
|November 6, 2013
PubMed
Summary
This summary is machine-generated.

Telocytes (TCs), a novel interstitial cell type, were found in the human esophagus. These cells, characterized by long Telopodes (Tps), may play a role in esophageal tissue repair.

Keywords:
EGFVEGFhuman oesophagusstromal synapsestelocytestelopodestissue repair

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Area of Science:

  • Gastroenterology
  • Cell Biology
  • Histology

Background:

  • Telocytes (TCs) are a recently identified class of interstitial cells present in various mammalian tissues.
  • Their presence and function in the human esophagus remain largely uncharacterized.

Purpose of the Study:

  • To investigate the presence and characteristics of Telocytes in the human esophagus.
  • To explore the potential role of esophageal Telocytes in tissue repair.

Main Methods:

  • Transmission electron microscopy (TEM) for ultrastructural analysis.
  • Immunohistochemistry (IHC) for cell identification.
  • Primary cell culture and ELISA for assessing secreted factors.

Main Results:

  • Typical Telocytes (TCs) with distinct cell bodies and long Telopodes (Tps) were identified in the human esophageal mucosa and muscular layers.
  • Telopodes (Tps) exhibited complex spatial arrangements and formed 'stromal synapses' with adjacent cells.
  • Primary esophageal TCs secreted increased levels of vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) in culture.

Conclusions:

  • The human esophagus harbors Telocytes (TCs) with characteristic morphology and intercellular connections.
  • Esophageal Telocytes (TCs) may contribute to tissue repair through the secretion of growth factors like VEGF and EGF.