Related Experiment Video
Updated: May 6, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
Screening of longevity-associated genes based on a comparison between dead and surviving populations
Wanxin An1, Li Zhang1, Benlan Gong1
1Dalian Blood Center, China; College of Medical Laboratory, Dalian Medical University, China.
Aim:
To investigate longevity-associated genes based on a comparison between dead and surviving populations.
Methods:
A total of 71 cases of dead individuals were treated as the death group, and healthy volunteers who were matched with the dead individuals based on sex and age were recruited as the survival group. Alleles of 13 CODIS STR loci were determined using the AmpFLSTR Profiler Plus PCR Amplification Kit. The cross-validation was performed based on differences between the two groups in both frequency values and ages.
Results:
The frequency value of the D18S51-17 alleles was significantly higher in the dead group than in the survival group (p<0.05), and the frequency value of the D2S1338-18 allele was statistically lower in the dead group than in the survival group (p<0.05). The mean age of the subjects with the D2S1338-18 allele was also significantly higher than that of the subjects without D2S1338-18, and no significant difference was observed with respect to the other three alleles.
Conclusions:
The results suggest that D2S1338-18 is associated with longevity.
Related Concept Videos
Genetic Screens
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
Comparing the Survival Analysis of Two or More Groups
Longitudinal Research
Kaplan-Meier Approach
Replicative Cell Senescence

