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An efficient algorithm to compute the posterior genotypic distribution for every member of a pedigree without loops

R L Fernando¹, C Stricker, R C Elston

¹Department of Animal Sciences, University of Illinois at Urbana-Champaign, 1207 West Gregory Drive, 61801, Urbana, IL, USA.

TAG. Theoretical and Applied Genetics. Theoretische Und Angewandte Genetik

|November 6, 2013

Abstract:

This paper describes a non-iterative, recursive method to compute the likelihood for a pedigree without loops, and hence an efficient way to compute genotype probabilities for every member of the pedigree. The method can be used with multiple mates and large sibships. Scaling is used in calculations to avoid numerical problems in working with large pedigrees.

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