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Aspartame and seizures.

P C Jobe1, J W Dailey

  • 1Department of Basic Sciences, College of Medicine of Peoria, Box 1649, 61656, Peoria, IL, USA.

Amino Acids
|November 6, 2013
PubMed
Summary
This summary is machine-generated.

Aspartame (L-aspartyl-L-phenylalanine methyl ester) does not cause seizures in humans or animals, even at high doses. Research confirms no link between aspartame consumption and seizure activity in various models.

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Area of Science:

  • Neuroscience
  • Toxicology
  • Food Science

Background:

  • The hypothesis that the artificial sweetener aspartame may promote seizures has been debated in scientific literature.
  • Previous studies presented conflicting evidence regarding aspartame's potential proconvulsive effects.

Purpose of the Study:

  • To comprehensively review existing biochemical, neurochemical, and behavioral research on the link between aspartame and seizure promotion.
  • To evaluate the safety of aspartame concerning seizure induction in various animal models and human populations.

Main Methods:

  • Review of published experimental studies, including biochemical, neurochemical, and behavioral assessments.
  • Analysis of data from rodent and primate models, as well as human studies involving individuals with and without epilepsy.
  • Examination of aspartame's effects under various dosage conditions, including doses significantly higher than typical human consumption.

Main Results:

  • Oral administration of aspartame did not induce convulsive seizures in rodents or primates.
  • Earlier reports suggesting aspartame-induced seizure facilitation in rodents were not replicated in subsequent, more rigorous studies.
  • No proconvulsive effects were observed in humans or other mammals, irrespective of epilepsy status, even at supra-physiological aspartame doses.
  • Available human data does not indicate an association between aspartame use and absence seizures.

Conclusions:

  • Aspartame is not a cause of convulsive seizures in humans or animal models.
  • The scientific evidence does not support the hypothesis that aspartame promotes seizure activity.
  • Current data suggests aspartame is safe concerning seizure liability across different populations and conditions.