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Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the

Xiao-Yan Qi1, Jonas G Diness, Bianca J J M Brundel

  • 1Research Center (X.-Y.Q., P.N., C.-T.W., H.H., M.H., M.A., S.N.), Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada; Cardiac and Circulatory Research Section (J.G.D., M.G.), Faculty of Health Sciences, University of Copenhagen and Acesion Pharma, Copenhagen, Denmark; Department of Clinical Pharmacology (B.J.J.M.B.), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Division of Experimental Cardiology (X.-B.Z., D.D.), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Chang-Gung Memorial Hospital and University Taoyuan (C.-T.W.), Taoyuan, Taiwan, China; Institute of Pharmacology (D.D.), Faculty of Medicine, University Duisburg-Essen, Essen, Germany.

Circulation
|November 6, 2013
PubMed
Summary

Calcium-dependent potassium (SK) channels influence heart rhythm and atrial fibrillation (AF) risk. Blocking these channels in dogs prolonged atrial refractoriness and reduced AF duration, suggesting potential anti-AF therapies.

Keywords:
action potentialsanti-arrhythmia agentselectrophysiologyion channels

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