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Updated: May 6, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Cholestatic jaundice as a paraneoplastic manifestation of prostate cancer
Tomomi Kuramoto1, Hiroya Senzaki, Hiroyuki Koike
1Department of Urology, Social Insurance Kinan Hospital, 46-70 Shinjou-chou, Tanabe-shi, Wakayama 646-8588, Japan.
Abstract:
Paraneoplastic syndrome associated with prostate cancer is extremely rare. We report a patient who presented with cholestatic jaundice without biliary duct obstruction, hepatic involvement, or infection. After a few detailed examinations, prostate cancer was diagnosed. After treatment with bicalutamide and leuprolide, the patient's symptoms and laboratory abnormalities were reversed. Cholestatic jaundice was regarded as a paraneoplastic manifestation in this patient. The patient remains symptom-free after 14-month followup. Paraneoplastic syndrome should be considered in case of cholestatic jaundice without biliary duct obstruction, hepatic involvement, or infection.
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