Development and evaluation of novel lozenges containing marshmallow root extract

Area of Science:

• Pharmacology
• Pharmaceutical Technology
• Natural Product Chemistry

Background:

• Irritated oropharyngeal mucosa and dry cough are common ailments.
• Traditional remedies often lack standardized delivery systems for consistent efficacy.
• Althaea officinalis L. (marshmallow) root contains polysaccharides with potential therapeutic benefits.

Purpose of the Study:

• To evaluate lozenges as an effective delivery system for Althaea officinalis L. root polysaccharide extract.
• To enhance the efficacy of preparations for treating oropharyngeal irritation and dry cough.
• To optimize polysaccharide extract delivery for convenient patient use.

Main Methods:

• Polysaccharide extract from Althaea officinalis L. root prepared using ultrasonification.
• Acute oral toxicity (LD50 p.o.) assessed in mice.
• Four distinct lozenge formulations developed with varied excipients.
• Physical characteristics (crushing resistance, friability, disintegration) and drug release profiles evaluated.

Main Results:

• The study successfully formulated and characterized four distinct lozenge models.
• Evaluation of physical properties and drug release demonstrated the feasibility of lozenges as a delivery system.
• Acute oral toxicity studies confirmed the safety profile of the marshmallow extract.

Conclusions:

• Lozenges represent a promising and convenient delivery system for Althaea officinalis L. root polysaccharide extract.
• Optimized lozenge formulations can improve the therapeutic efficacy for oropharyngeal discomfort and cough.
• Further research can focus on clinical validation of these enhanced marshmallow-based preparations.