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Intracranial Pharmacotherapy and Pain Assays in Rodents
Published on: April 9, 2019
[Drug therapy of pain: reason overwhelmed by emotion?]
1Clinique rhumatologique, Hôpital Triemli, Birmensdorferstrasse 497 8063 Zurich. robert.theiler@triemli.zuerich.ch
Abstract:
Successful pain management represents a daily medical challenge for in- and outpatients. The analysis of Swiss drug unit sales data between year 2000 and 2010 of an array of selected analgesic drugs (non-steroidal antiinflammatory drugs (NSAIDs), paracetamol, metamizole, and opioids) identified current trends. While the overall number of treatment-days with analgesics has markedly and steadily increased and opioid usage may be considered as consistent with recently widened indications to non-tumor pain, the use of NSAIDs (whether COX-2-selective or not) entered stagnation and usage of the least well documented substances (paracetamol and metamizole) has more than decupled. These observations are put into perspective with the findings of a brief literature review aimed at summarizing the latest research developments in the field of analgesic drug therapy.
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