Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pan-immune-inflammation value predicts 2-year recurrence after chemoradiotherapy in nasopharyngeal carcinoma.

Frontiers in medicine·2026
Same author

Anthropogenic Contributions to Wintertime Terpenes: Insights from Multi-site Online Observations and Machine Learning Analysis in Shenzhen, Southern China.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Protein lactylation in health and diseases: molecular mechanisms, biological significance, and clinical implications.

Signal transduction and targeted therapy·2026
Same author

Tumor-versus-nonmalignant quantitative drug sensitivity profiling identifies capivasertib as a selective therapeutic candidate for nasopharyngeal carcinoma.

SLAS discovery : advancing life sciences R & D·2026
Same author

Hybrid Polymer-Inorganic Salt Hydrate Materials: Applications for Heat Storage and Beyond.

ACS applied materials & interfaces·2026
Same author

Ultrasensitive, low-input detection of avocado sunblotch viroid via RPA-CRISPR and nanopore-array single-bead fluorescence readout.

Microsystems & nanoengineering·2026

Related Experiment Video

Updated: May 6, 2026

Orientational Transition in a Liquid Crystal Triggered by the Thermodynamic Growth of Interfacial Wetting Sheets
06:26

Orientational Transition in a Liquid Crystal Triggered by the Thermodynamic Growth of Interfacial Wetting Sheets

Published on: May 15, 2017

6.4K

Large-amplitude, reversible, pH-triggered wetting transitions enabled by layer-by-layer films.

Yiming Lu1, Mohammad Amin Sarshar, Ke Du

  • 1Department of Chemistry, Chemical Biology and Biomedical Engineering, ‡Department of Mechanical Engineering, and §Department of Chemical Engineering and Material Science, Stevens Institute of Technology , Hoboken, New Jersey 07030, United States.

ACS Applied Materials & Interfaces
|November 7, 2013
PubMed
Summary

We developed pH-responsive layer-by-layer (LbL) hydrogels that induce significant surface wetting transitions on microstructured surfaces. These smart hydrogels show potential for controlling flow, bioadhesion, and detecting analytes near physiological pH.

More Related Videos

Procedure for the Transfer of Polymer Films Onto Porous Substrates with Minimized Defects
05:02

Procedure for the Transfer of Polymer Films Onto Porous Substrates with Minimized Defects

Published on: June 22, 2019

6.1K
Patterning via Optical Saturable Transitions - Fabrication and Characterization
08:19

Patterning via Optical Saturable Transitions - Fabrication and Characterization

Published on: December 11, 2014

6.0K

Related Experiment Videos

Last Updated: May 6, 2026

Orientational Transition in a Liquid Crystal Triggered by the Thermodynamic Growth of Interfacial Wetting Sheets
06:26

Orientational Transition in a Liquid Crystal Triggered by the Thermodynamic Growth of Interfacial Wetting Sheets

Published on: May 15, 2017

6.4K
Procedure for the Transfer of Polymer Films Onto Porous Substrates with Minimized Defects
05:02

Procedure for the Transfer of Polymer Films Onto Porous Substrates with Minimized Defects

Published on: June 22, 2019

6.1K
Patterning via Optical Saturable Transitions - Fabrication and Characterization
08:19

Patterning via Optical Saturable Transitions - Fabrication and Characterization

Published on: December 11, 2014

6.0K

Area of Science:

  • Materials Science
  • Surface Chemistry
  • Polymer Science

Background:

  • Controlling surface wettability is crucial for various applications, including microfluidics and biomedical devices.
  • Stimuli-responsive hydrogels offer tunable surface properties.
  • Microstructuring surfaces enhances control over wetting phenomena.

Purpose of the Study:

  • To investigate the use of layer-by-layer (LbL) hydrogels made of amphiphilic polymers for inducing sharp wetting transitions.
  • To explore the effect of polymer hydrophobicity on wetting behavior and transition pH.
  • To demonstrate the potential of these hydrogels for analyte detection.

Main Methods:

  • Fabrication of LbL hydrogel coatings using poly(2-alkylacrylic acids) (PaAAs) with varying hydrophobicity on micropillar-patterned silicon substrates.
  • Characterization of surface wettability using contact angle (CA) measurements at different pH values.
  • Analysis of droplet behavior, including contact angle hysteresis and Wenzel state.

Main Results:

  • Hydrophilic poly(methacrylic acid) (PMAA) LbL hydrogels supported complete wetting (CA=0°).
  • More hydrophobic PaAAs (PEAA, PPAA, PBAA) exhibited large wetting transitions (CA from 110-125° to 0°) with increasing transition pH (6.2-8.4) correlating with hydrophobicity.
  • Acidic pH resulted in a 'sticky droplet' behavior and Wenzel state, while transitions near physiological pH were observed.

Conclusions:

  • LbL hydrogels composed of pH-responsive amphiphilic polymers can effectively induce large-amplitude wetting transitions on microstructured surfaces.
  • The tunable transition pH and wetting behavior make these coatings promising for applications requiring external stimuli control, such as flow modulation and bioadhesion.
  • The observed wettability changes can be utilized for sensitive detection of positively charged analytes in solution.