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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Rheumatic Heart Disease I: Introduction01:23

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Ankle Joint01:10

Ankle Joint

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The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
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Knee Joint01:23

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The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Updated: May 6, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
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A gut feeling about arthritis.

Diane Mathis1

  • 1Diane Mathis is at the Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, United States dm@hms.harvard.edu.

Elife
|November 7, 2013
PubMed
Summary
This summary is machine-generated.

Newly diagnosed rheumatoid arthritis patients show higher levels of Prevotella bacteria in their gut. This finding highlights a potential link between gut microbes and early rheumatoid arthritis development.

Keywords:
arthritisautoimmunityinflammationmetagenomicsmicrobiotarheumatoid

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Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
  • The gut microbiota plays a role in immune system regulation.
  • Alterations in gut bacteria have been observed in various inflammatory conditions.

Purpose of the Study:

  • To investigate the gut microbial composition in patients newly diagnosed with rheumatoid arthritis.
  • To identify specific bacterial taxa associated with early-stage RA.

Main Methods:

  • 16S rRNA gene sequencing was used to analyze fecal samples.
  • Comparison of microbial diversity and abundance between RA patients and healthy controls.

Main Results:

  • Patients with recent rheumatoid arthritis diagnoses exhibited a significant enrichment of microbes from the Prevotella genus.
  • No significant differences in overall microbial diversity were observed between groups.

Conclusions:

  • The Prevotella genus is a potential biomarker for early rheumatoid arthritis.
  • Gut dysbiosis, specifically Prevotella enrichment, may contribute to RA pathogenesis.