Related Experiment Video

Updated: May 6, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

6.8K

Renal cell carcinoma development and miRNAs: a possible link to the EGFR pathway

Francisca Dias1, Ana L Teixeira, Juliana I Santos

  • 1Molecular Oncology Group, Portuguese Institute of Oncology, Rua Dr António Bernardino de Almeida, 4200-072 Porto, Portugal.

Pharmacogenomics
|November 7, 2013
PubMed

Insights

Renal cell carcinoma (RCC) is a common kidney cancer often found late. This review explores microRNAs (miRNAs) that may regulate the EGF receptor pathway, impacting RCC development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Renal cell carcinoma (RCC) is the most common adult kidney cancer.
  • Many RCC cases are diagnosed incidentally, often at advanced stages due to lack of screening.
  • MicroRNAs (miRNAs) are small non-coding RNAs crucial for gene expression and cellular processes.

Purpose of the Study:

  • To review the role of microRNAs (miRNAs) in renal cell carcinoma (RCC) development.
  • To investigate the potential involvement of miRNAs in modulating the Epidermal Growth Factor (EGF) receptor signaling pathway in RCC.
  • To identify potential miRNA biomarkers for RCC.

Main Methods:

  • Literature review focusing on miRNAs, EGF receptor signaling, and renal cell carcinoma.
  • Analysis of existing studies on gene expression and pathway regulation in RCC.
  • Identification of miRNAs implicated in EGF receptor pathway modulation.

Main Results:

  • The Epidermal Growth Factor (EGF) receptor signaling pathway is frequently deregulated in various cancers, including RCC.
  • Specific miRNAs have been identified as potential regulators of the EGF receptor pathway.
  • These miRNAs may play a significant role in the development and progression of renal cell carcinoma.

Conclusions:

  • MicroRNAs (miRNAs) are implicated in the pathogenesis of renal cell carcinoma (RCC).
  • Modulation of the EGF receptor pathway by specific miRNAs represents a potential mechanism in RCC development.
  • Further research into these miRNA-pathway interactions could lead to novel diagnostic and therapeutic strategies for RCC.

More Related Videos

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

14.2K
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

5.8K

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.5K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
3.7K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.1K