Related Experiment Video
Updated: May 6, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Three new pseudopolymorphs of 6-aminouracil
Valeska Gerhardt1, Michael Bolte
1Institut für Organische Chemie und Chemische Biologie, Goethe-Universität Frankfurt, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany.
Abstract:
Since 6-aminouracil derivatives show diversified use in various fields of application, we crystallized 6-aminouracil to examine its preferred hydrogen-bonding frameworks. 6-Aminouracil shows two rigid hydrogen-bonding sites, viz. one acceptor-donor-acceptor (ADA) site and one donor-donor-acceptor (DDA) site. During various crystallization attempts, we obtained three structures, namely two dimethylacetamide monosolvates, C4H5N3O2·C4H9NO, and a 1-methylpyrrolidin-2-one monosolvate, C4H5N3O2·C5H9NO. In all three structures, R2(1)(6) N-H...O hydrogen-bonding patterns link the molecules to their respective solvent molecules. The formation of R2(2)(8) N-H...O hydrogen-bond motifs between 6-aminouracil molecules can only be found in two-dimensional frameworks, whereas R3(3)(14) N-H...O patterns are present when zigzag chzins of 6-aminouracil molecules are formed.
More Related Videos
08:46Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
Published on: July 26, 2018
09:04A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
Related Concept Videos
Nomenclature of Aryl and Heterocyclic Amines
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview
Nomenclature of Secondary and Tertiary Amines
Nomenclature of Primary Amines
Structure of Amines
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence