Clinical experience in oral surgery with human fibrin sealant

Fibrin sealant is a two-component product consisting in principle of fibrinogen and thrombin. When it is activated, fibrin (the clot) is formed. Being a natural product, the versatility of its use in the human body is great. No side-effects or complications have been described. It has been tested clinically in oral surgery and found to be very effective in the fixation of mucosal and skin grafts in the oral cavity; as a surgical dressing for the palate or on the lips; in osseous reconstruction after mixture with bone-chips; and finally in the treatment of chronic sclerotizing osteomyelitis of the mandible after the addition of metronidazole. It also has uses in many other fields of surgery.