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Area of Science:

  • Biomedical Engineering
  • Physiology
  • Drug Discovery

Background:

  • Micro-physiological systems, known as "organs-on-chips", are increasingly sophisticated in replicating human and animal physiology.
  • These systems are crucial for understanding physiological and pathological processes.
  • They offer significant potential for drug development and toxicity screening.

Purpose of the Study:

  • To review the latest advancements in multi-organ-on-chip designs and applications.
  • To discuss the potential of organ-on-chip technology in enhancing human physiology understanding.
  • To explore the transformative impact on drug discovery and preclinical testing.

Main Methods:

  • Review of state-of-the-art designs for multi-organ-on-chip systems.
  • Analysis of current examples and applications in research.
  • Discussion of technological advances and challenges.

Main Results:

  • Significant progress in developing complex "organs-on-chips" systems.
  • Demonstrated utility in providing insights into physiological and disease processes.
  • Highlighting recent technological innovations in the field.

Conclusions:

  • Organ-on-chip technology holds immense potential for advancing physiological research.
  • This technology can accelerate and transform drug discovery and preclinical testing.
  • Further technological development is needed to fully realize the potential of these systems.