Related Experiment Video
Updated: May 6, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
The biological tests used in acute-phase of inflammation in bone infection : Clinical study
J J Morales1, J Cabo, A F Sabate
1Service of Orthopedic Surgery and Traumatology, Ciudad Sanitaria y Universitaria de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain.
Abstract:
We present a comparative study of different biological tests in the acute phase of inflammation. The study was performed in 80 patients after surgical procedures in septic cases. We have compared the levels of C-Reactive Protein (CRP), C3, C3a, C4, T(o), sedimentation rate, and the leucocyte count. The analysis was made before surgery and every week until the ninth week after surgery. The variations in CRP which ocurred very early were extensive. The increase ranged between 200 and 600% after the surgical procedure. In cases without complications the CRP level returned to normal within 20 days. The study showed the CRP as the most specific and sensitive biological test of the acute phase of inflammation. However this biological test cannot differentiate between an acute infective and a severe inflammatory process.
More Related Videos
18:40Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
Published on: October 16, 2014
09:09Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
Published on: March 14, 2019
Related Concept Videos
Acute Inflammation I: Cellular Phase
Acute Inflammation I: Inflammatory Response
Acute Pyelonephritis II: Diagnostic Studies and Management
Myocarditis II: Clinical Features and Diagnostic Tests