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Related Concept Videos

Bone Disorders01:29

Bone Disorders

8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Fractures: Bone Repair01:27

Fractures: Bone Repair

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Gross Anatomy of Bone01:17

Gross Anatomy of Bone

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The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in...
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Bone Remodeling and Repair01:31

Bone Remodeling and Repair

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[Peritrochanteric fractures treated with a lamina-plate with stay].

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie·2017
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Oncogenic role of PDK4 in human colon cancer cells.

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Introduction.

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Related Experiment Video

Updated: May 6, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
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[Massive osteolysis : two cases displaying extreme clinical aspects].

R Pem1, D Leclerc, E Gagneux

  • 1Service de Chirurgie, Centre Hospitalier de Pontarlier, F-25300, Pontarlier.

European Journal of Orthopaedic Surgery & Traumatology : Orthopedie Traumatologie
|November 7, 2013
PubMed
Summary

Massive osteolysis presents with diverse clinical features, affecting young men differently. This study reviews cases and literature to aid diagnosis and guide treatment for this rare bone disorder.

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Area of Science:

  • Orthopedics
  • Radiology
  • Pathology

Context:

  • Presents two distinct cases of massive osteolysis in young males.
  • Highlights varied clinical presentations and disease progression.
  • Underscores the importance of imaging in diagnosis.

Purpose:

  • To describe two contrasting cases of massive osteolysis.
  • To review the literature on massive osteolysis.
  • To clarify pathogenic aspects, classification, and diagnosis.

Summary:

  • Case 1: A 28-year-old man with osteolysis of the distal ulna, discovered incidentally after trauma.
  • Case 2: A 17-year-old male with pelvic osteolysis, experiencing complications like chylothorax.
  • Literature review aids in understanding pathogenesis, classification, and diagnostic keys.

Impact:

  • Provides insights into the varied clinical spectrum of massive osteolysis.
  • Offers guidance for diagnosis and management of this rare condition.
  • Suggests cautious treatment approaches for benign forms of the disease.