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Updated: May 6, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
Published on: May 10, 2016
Health risk assessment for toxic emissions from a manufacturing facility
1Department of Civil Engineering, The University of Toledo, 43606, Toledo, Ohio, USA.
Abstract:
This paper presents the risk associated with the release of toxic chemicals from a manufacturing facility, following the State of California's approach to risk assessment. The facility emits five toxic substances from eight stacks. The building downwash is considered during dispersion calculations. The zone of impact, identified using a risk criteria (i.e. excess cancer risk of 10 in a million), is located in the southeast quandrant from the plant. The size of the impact area is 3.3 km(2). The cancer and non-cancer effects are considered for chromium (VI), benzene, formaldehyde, gasoline vapors, methylene chloride, and selenium using the California Air Pollution Control Officers Association Guidelines. No significant non-cancer effects are found due to the emissions. The maximum calculated risk is 1.197×10(-5) and is an extremely conservative value. Analysis shows that the use of realistic assumptions for exposure duration and unit risk factors during the risk calculations could reduce the zone of impact to 0 km(2).
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