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In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox
Published on: August 28, 2019
Time-to-event analyses of ecotoxicity data
1Savannah River Ecology Laboratory, University of Georgia, P.O. Drawer E, Aiken, South Carolina, USA.
Abstract:
: Intensity and duration of exposure dictate the effect of a toxicant. Consequently, any assessment of ecological risk that does not include a sound understanding of both concentration and duration effects is compromised. This being the case, it is surprising that the predominant approach in ecotoxicology (concentration-effect modeling) inefficiently includes exposure duration. Ecological risk assessment can be enhanced with time-to-event models that can easily include concentration, exposure duration, and other important covariates. Time-to-event methods are described and linkage made to relevant ecological techniques, i.e. life table analyses and genetic selection models.
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